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Dr. Svetlana Mojsov receives award for GLP-1 Discovery
Dr. Mojsov’s research grant from Diabetes Action’s 1993 Annual Report and Overview
Dr. Svetlana Mojsov received the Distinguished Medical Science Award at the 2025 Friends of the National Library of Medicine Awards Gala for her “groundbreaking contributions to the development of glucagon-like peptide 1 (GLP-1) receptor agonists, which have transformed the treatment of type 2 diabetes and obesity, benefiting millions worldwide.”
Diabetes Action is proud to have funded some of Dr. Mojsov’s initial research on GLP-1 in the early 1990’s. Her work directly led to the development of semaglutide for the treatment of type 2 diabetes. Dr. Mojsov has received many accolades for her discovery including being named to the TIME100 list of Most Influential People of 2024 and receiving the prestigious 2024 Lasker~DeBakey Clinical Medical Research Award.
This image from Diabetes Action’s 1993 annual report shows Dr. Mojsov’s research grant at Rockefeller University. The grant, which was one of the first grants ever made by Diabetes Action, was titled “Studies on the Mechanism of Stimulation of Insulin Secretion by the Newly Discovered Glucagon-Like Peptide 1”. The goal of the research was described as:
It is well known that the proper secretion of insulin from the pancreas in response to elevated levels of glucose in circulation is central to the maintenance of glucose homeostasis. Dr. Mojsov has recently discovered that a new peptide, called glucagon-like peptide-1 that is encoded by the glucagon gene and is released in the intestine, is one of the most potent insulin releasing peptides described to date. Recent studies suggest that glucagon-like peptide-1 can be used therapeutically in the treatment of the disorders of glucose inbalance manifested in Type II Diabetes (NIDDM). However, before such a treatment becomes clinically feasible, a better understanding of the mechanism of insulin stimulation by this peptide-1 is needed. Dr. Mojsov hopes the results of her studies will provide insights into this mechanism and contribute to the development of a new generation of “gut-based” therapeutic agents for treatment of Type II Diabetes.
Dr. Mojsov acknowledged the support from Diabetes Action in her Distinguished Medical Science Award acceptance speech and noted that the small grant helped supplement her NIH funding and allowed her to expand her research on GLP-1.
Diabetes Action commends Dr. Mojsov for her outstanding contributions to medical research, which have benefited millions of people around the world. In addition, we extend our sincere thanks for her unwavering support of the diabetes research community. For more than two decades, Dr. Mojsov has generously volunteered her expertise as a grant reviewer as part of Diabetes Action’s volunteer Medical Advisory Board, helping to advance innovative research and support the next generation of scientists.
Recently Published Research Funded by Diabetes Action
Researcher:
Dongmin Liu, PhD
Professor
Virginia Polytechnic Institute and State University
Blacksburg, VA
Olive-derived elenolic acid surpasses metformin and rivals liraglutide in managing blood glucose and obesity in a mouse model of type 2 diabetes
Yao Wang, Hana Alkhalidy, Xinyi Cao, Reagan Vaughan, MD Abu T. Rachi, Bin Xu, Balaji Kale, Abeje Silte, Jennifer Rainville, Georgia E. Hodes, Yan Zhang, Dongmin Liu, “Olive-derived elenolic acid surpasses metformin and rivals liraglutide in managing blood glucose and obesity in a mouse model of type 2 diabetes” The Journal of Nutritional Biochemistry, Volume 150, 2026, https://doi.org/10.1016/j.jnutbio.2025.110206.
Researcher:
Gregory C. Henderson
Assistant Professor
Purdue University
West Lafayette, IN
The Plasma Free Fatty Acid Carrier Proteome is Altered in Diet-Induced and Genetically Obese Mice
K.Tomoo, Y.Zhang, A. Z. D.Portalatin, and G. C.Henderson, “The Plasma Free Fatty Acid Carrier Proteome is Altered in Diet-Induced and Genetically Obese Mice,” Obesity34, no. 6 (2026): 1300–1313, https://doi.org/10.1002/oby.70214.
Researcher:
Prasanth Chelikani, PhD
Professor
Texas Tech University
Amarillo, TX
Maternal Protein Restriction and Branched-Chain Amino Acid Supplementation Differentially Affect Maternal Energy Balance and Impair Offspring Growth
Redrovan D, Patra S, Aziz MT, Gorton MW, Chavez EA, Frederiksen S, Rowe J, Pezeshki A, Chelikani PK. Maternal Protein Restriction and Branched-Chain Amino Acid Supplementation Differentially Affect Maternal Energy Balance and Impair Offspring Growth. Nutrients. 2026 Jan 20;18(2):322. doi: 10.3390/nu18020322.
Prebiotics pectin and resistant starch-type 4 stimulate peptide YY and cholecystokinin to promote satiety, and improve gut microbiota composition
Patra S, Everhart Nunn SL, Levent G, Chelikani PK. Prebiotics pectin and resistant starch-type 4 stimulate peptide YY and cholecystokinin to promote satiety, and improve gut microbiota composition. FASEB J. 2025 Mar 31;39(6):e70457. doi: 10.1096/fj.202403239R. PMID: 40085424.
Microencapsulated Propionate and Butyrate Improved Energy Balance and Gut Microbiota Composition in Diet-Induced Obese Rats
Patra S, Chelikani PK. Microencapsulated Propionate and Butyrate Improved Energy Balance and Gut Microbiota Composition in Diet-Induced Obese Rats. Nutrients. 2025; 17(13):2180. https://doi.org/10.3390/nu17132180
Researcher:
Vincenza Cifarelli, PhD
Assistant Professor of Pharmacology and Physiology
Saint Louis University School of Medicine
St. Louis, MO
How lipids speak to nerves
V. Cifarelli, How lipids speak to nerves, Proc. Natl. Acad. Sci. U.S.A. 122 (52) e2530035122, https://doi.org/10.1073/pnas.2530035122 (2025).
Researcher:
Bhagirath Chaurasia, PhD
Assistant Professor
University of Iowa
Iowa City, IA
Ceramide signaling in immunity: a molecular perspective
Thakkar, H., Vincent, V. & Chaurasia, B. Ceramide signaling in immunity: a molecular perspective. Lipids Health Dis 24, 225 (2025). https://doi.org/10.1186/s12944-025-02642-2
Researcher:
Liang-Jun Yan, Ph.D.
Professor of Pharmaceutical Sciences
University of North Texas Health Science Center
Fort Worth, TX
Beneficial Effects of Butyrate on Kidney Disease
Diep TN, Liu H, Yan L-J. Beneficial Effects of Butyrate on Kidney Disease. Nutrients. 2025; 17(5):772. https://doi.org/10.3390/nu17050772
Researcher:
Andrew C. Shin, PhD
Assistant Professor
Texas Tech University
Lubbock, TX
BCAAs acutely drive glucose dysregulation and insulin resistance: role of AgRP neurons
Shah, H., Gannaban, R.B., Haque, Z.F. et al. BCAAs acutely drive glucose dysregulation and insulin resistance: role of AgRP neurons. Nutr. Diabetes 14, 40 (2024). https://doi.org/10.1038/s41387-024-00298-y
Researcher:
Layla Al-Nakkash, Ph.D.
Professor of Physiology
Midwestern University
Glendale, AZ
Deleterious impacts of Western diet on jejunum function and health are reversible
Deleterious impacts of Western diet on jejunum function and health are reversible. Sarah Carpinelli, John Ahlert, Maxwell Rubin, Alex Aratani, Emma Smith, Dana Floyd, Ross M. Potter, and Layla Al-Nakkash American Journal of Physiology-Gastrointestinal and Liver Physiology 2025 328:2, G83-G93 10.1152/ajpgi.00160.2024
Researcher:
EunSeok Cha, Ph.D., MPH, MSN, CDE, RN
Assistant Professor
Emory University Nell Hodson Woodruff School of Nursing
Atlanta, GA
Longitudinal changes in diet quality and food intake before and after diabetes awareness in American adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study
Cha E, Choi Y, Bancks M, Faulkner MS, Dunbar SB, Umpierrez GE, et al. Longitudinal changes in diet quality and food intake before and after diabetes awareness in American adults: the Coronary Artery Risk Development in Young Adults (CARDIA) study. BMJ Open Diabetes Research & Care. 2024;12:e003800. https://doi.org/10.1136/bmjdrc-2023-003800
Researcher:
Gaetano Santulli, MD
Assistant Professor of Medicine
Albert Einstein College of Medicine
Bronx, NY
A Novel Imaging Marker for Asymptomatic Cerebrovascular Lesions in Hypertension
Gaetano Santulli, Marco Savino, Klara Komici, Pasquale Mone, Luigi Savino, Stanislovas S Jankauskas, A Novel Imaging Marker for Asymptomatic Cerebrovascular Lesions in Hypertension, American Journal of Hypertension, Volume 37, Issue 11, November 2024, Pages 859–860, https://doi.org/10.1093/ajh/hpae100
Researcher:
Li Wen, MD, PhD
Associate Professor in Medicine
Yale University School of Medicine
New Haven, CT
Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Pai Wang, Xin Yang, Luyao Zhang, Sha Sha, Juan Huang, Jian Peng, Jianlei Gu, James Alexander Pearson, Youjia Hu, Hongyu Zhao, F. Susan Wong, Quan Wang & Li Wen, Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis, Nature Communications, volume 15, Article number: 4232 (2024) https://doi.org/10.1038/s41467-024-48611-8
Researcher:
Douglas Sobel, MD
Professor of Pediatrics, Chief Pediatric Endocrinology
Georgetown University
Washington, DC
Preparation of PLGA Microspheres Using the Non-Toxic Glycofurol as Polymer Solvent by a Modified Phase Inversion Methodology
Sobel D, Ramasubramanian B, Sawhney P, Parmar K. Preparation of PLGA Microspheres Using the Non-Toxic Glycofurol as Polymer Solvent by a Modified Phase Inversion Methodology. Polymers. 2024; 16(3):434. https://doi.org/10.3390/polym16030434